Combining several lineage-tracing approaches, we show that, upon Pax4-mediated α-to-β-like cell conversion, pancreatic duct-lining precursor cells are continuously mobilized, re-express the developmental gene Ngn3, and successively adopt a glucagon+ and a β-like cell identity through a mechanism involving the reawakening of the epithelial-to-mesenchymal transition.
Regenerating muscle fibres transiently express the developmental form of myosin heavy chain (dMyHC; Novocastra, NCL-MHCd) and newly regenerated fibres have their nuclei in the centre and not in the periphery.
Perhaps most importantly, however, we need to ensure that newly emerging therapeutics intended to target tumor-initiating cancer stem cells are evaluated carefully for their ability to eliminate all sources of such cells completely, lest they find a way to express the developmental plasticity with which they appear to be endowed.
In contrast, CCL-chr5a, CCLchrUi, cxcl12a, and ccl1 were expressed throughout the developmental stages from 0 hpf to adults, although their expression levels in eggs at 0 hpf were quite low compared to those of the other embryonic stages.
The class Ib genes that were expressed widely in the adult tissues (H2-Q4, - Q7, - T24, - T23, - T22 and - M3) also tended to be expressed throughout the developmental stages.
These two short 'antisense' transcripts are differentially expressed during the developmental cycle.
OeLS was almost exclusively expressed at the developmental stage when the highest level of this compound was detected.
Only 151 of the 7,922 probesets were defined as stably expressed across the developmental, stress and/or entire dataset.
Moreover, as orb transcript is the earliest to be differentially expressed during the developmental time course, we propose that Orb might play a major role in determining oocyte fate.
miR-306 is fairly uniformly expressed across the developmental stages, as judged by the number of reads, whereas miR-263 is dynamically regulated from the larva to adult stages.
