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These variations can cause genes to be expressed (switched on) in slightly different ways among individuals.
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Even though DN memory B cells mainly express switched Ig isotypes, they have a reduced rate of SHM compared to post-switch B cells.
To determine the distribution of B cells expressing switched immunoglobulin isotypes in the Tasmanian devil, sections of lymphoid organs were labeled using immunohistochemistry with antibodies against CD79b, IgM, and IgG.
The idea of storing the memory of a transient stimulus in the form of a given spatial distribution of active cells has been used in the bi-stable model network expressing switching between global OFF and multiple ON activity states which was proposed as a model of working memory [12].
They can affect which genes are "expressed", or switched on or off, with potentially profound consequences for health.
Finally we demonstrate that a firing-rate model network consisting of two oscillatory populations of excitatory cells interconnected by cross-inhibition and electrical coupling expresses switching between patterns according to rules similar to those found for two relaxation oscillators.
Moreover, for a given set of synaptic strengths, multiple stable patterns can be expressed and switching between them can be induced by a suitable transient external stimulus.
In fact, in SLE patients we showed that, even in those with 'complete' peripheral B cell depletion, it is possible to detect residual B cells that predominantly express a switched memory phenotype [ 8].
Hysteresis loops expressing resistance switching behaviour were observed in Sn-doped CeO2−δ nanorods.
Then, we couple it with Hidden Markov Model (HMM) to express the switching characteristics of the disturbances.
It is shown that under conditions related to minimum dwell time of each mode, one can express the switching law as a linear combination of the system input/output samples.
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