In addition, organs commonly associated with being sites of breast cancer metastasis, such as lung, liver, lymph node, brain and bone, constitutively express the sole ligand for CXCR4, CXCL12 (Muller et al, 2001).
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Cdc42CTRac1 was functional, when expressed as the sole Cdc42 copy, for viability (Figure 3B).
We compared the ability of Ssa1p-Ssa4p from Saccharomyces cerevisiae and Ssa5p-Ssa8p from the evolutionary distant yeast Yarrowia lipolytica to perform Hsp70-dependent tasks when expressed as the sole Hsp70 for S. cerevisiae in vivo.
The major difference we identified is in the expression of the rodent and human HNF1A genes, which code for three isoforms in humans, but was expressed as a sole isoform, HNF1A(A) in all tissues tested in rodents.
Similarly, Rac1CTCdc42 was functional, when expressed as a sole Rac1 copy, for embedded filamentous growth, suggesting that Rac1 nuclear accumulation is not required for embedded filamentous growth (Figure 3C).
When Gtr1S20L is expressed as the sole version of Gtr1, cells are extremely sick.
When expressed as the sole source of Ssa Hsp70, Ssa2 supports stable [URE3] propagation, but Ssa1 antagonizes [URE3].
In fact, in one out of four tumors AR are expressed as the sole sex hormone receptor.
These 60-mer probes were designed against the 3'end sequences of Senegalese sole expressed sequence tags (ESTs) [ 27].
