Taken together, these observations suggest that these two clusters are similarly expressed, regulate common target genes and are functionally conserved in ESCs derived from various species.
Although our results do not preclude the development of gene therapy approaches to express regulated TGF-β1 systemically to downmodulate the immune response, the results suggest that any clinical application of local TGF-β1 gene transfer should proceed with caution.
However, the SSTFs they express regulate each other and also define the function of the population.
To determine whether SUMOs are expressed and regulated by glucose in mesangial cells, we used Western blot and RT-PCR for detection.
By linking data from both ChIP-on-chip and expression microarrays, a series of differentially expressed genes regulated by changes of H3K9Ac and H3K9Me2 were identified.
However, lncRNAs are temporally and spatially expressed and regulated, and motif-based sequence analysis cannot capture the dynamic regulation of lncRNAs by TFs in different cell lines.
In contrast, highly expressed or regulated genes with unknown function can be further studied in identifying pathogenicity factors.
In our study, Rubisco subunits (small and large chain) related to photosynthesis were differentially expressed and regulated by combination treatments and between genotypes (Tables 1 and 2).
For analysis of the genes expressed and regulated during diurnal conditions, we analyzed the diurnal photoperiod response data set (Mockler et al. 2007; Filichkin et al. 2011) available from the DIURNAL project website (http://diurnal.mocklerlab.org/).mocklerlab.org/
However, when, where, what and how much a gene is expressed are regulated precisely and dynamically at multiple levels, including at transcription, mRNA maturation, alternative splicing, and translation levels.
