Sentence examples for expressed processed and presented from inspiring English sources

Some of the altered amino acid peptides can be expressed, processed, and presented on the cell surface by MHC molecules and subsequently recognized by T cells.

We further demonstrate that in vitro-transcribed RNA can be delivered to DCs where the encoded antigens are expressed, processed, and presented by MHC class I molecules on the cell surface.

Cytokine production (IFN-γ, IL-10) by TyrTCR-transduced cells was also detected following co-culture with a melanoma tumor cell line expressing tyrosinase naturally processed and presented in the context of HLA-A*0201 HLA-A*0201shown).

Current strategies of targeting neoantigens for cancer treatment are all based on TCRs that recognize mutant peptide/MHC complexes, because most of the neoantigens identified are expressed inside the tumor cells and processed and presented by MHC molecules (Gubin et al., 2014; Robbins et al., 2013; Tran et al., 2014).

MOG91 108 expressed by the DNA vaccine is processed and presented on MHC II by dendritic cells to T cells.

Moreover, this clone recognized the HER-2/neu+ SKbreasteast cancer cell line induced to express HLA-DR, thus demonstrating that HER2 776 788) represents a naturally processed and presented epitope.

These peptide-specific CTL could also recognise HLA-A2+ melanoma cells expressing MC1R, demonstrating that the MC1R derived peptides are naturally processed and presented by MHC class I on the surface of melanoma cells (Salazar-Onfray et al, 1997).

If the peptide-specific CTLs do not recognize tumour cells expressing the whole protein, this suggests that the peptide may not be naturally processed and presented.

During indirect presentation, peptides derived from donor MHC class I or MHC class II molecules are processed and presented to CD4+ T-cells by host antigen presenting cells expressing the recipient's MHC class II molecules.

AAYs expressed inside the selected epitopes were easily recognized by proteasomes, and the full-length protein was more easily processed and presented in vivo.

Unlike for TCR recognition, the antigen does not need to be processed and presented by MHC and therefore the same CAR-based approach can be used in all patients who express the same tumour antigen regardless of HLA type.