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The genes enriched in nucleic acid metabolic processes were expressed lower than the 25th percentile.
A large fraction of amplified genes are expressed lower than expected in aneuploid isolates.
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AChR cluster numbers and lengths in control siRNA- and cortactin siRNA-transfected myotubes (150 or more each) were measured (see above) and data from four separate siRNA-transfection experiments revealed that the average values of these parameters were reduced by ∼40% in myotubes expressing lower than normal levels of cortactin (Fig. 6, H I).
Interestingly, 90% of ccRCC express lower than normal levels of USP10, possibly leading to reduced p53 activation (Yuan et al, 2010).
Following stimulation with anti-CD3, both CD8+ TCCs increased the expression of CD107a, a marker of degranulation and cytotoxic activity, although TCC4-1 expressed lower levels than TCC17-2 indicating lower cytotoxic potential (Fig. 2D).
It has been shown that poorly differentiated lung adenocarcinoma and squamous cell carcinoma expressed lower levels than well-differentiated and moderate-differentiated cancers [ 20].
A majority of the genes that are up-regulated in ESCs compared to fibroblasts ("ESC genes") are expressed lower in iPSCs than in ESCs.
Notably, PC3 cells, although they expressed lower PCA3 levels than LNCaP cells, showed greater inhibition of cell survival after PCA3 silencing.
Also, Hdac6 overexpression ES cells expressed lower γH2AX protein levels than did WT ES cells (Fig. S1C).
All analyzed cell lines expressed lower RAB25 mRNA levels than OKF6-Tert1 keratinocytes (Fig. 4A).
Undifferentiated tumours expressed lower PHD3 mRNA levels than the well-differentiated specimens.
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