CDK2AP1 is a highly conserved and ubiquitously expressed gene located on human chromosome 12q24 and is a 115-aa nuclear polypeptide that is downregulated in ∼70% of oral cancers [2], [3].
Gender differences were apparent for a number of differentially expressed genes located on sex chromosomes.
These results suggest that ABC2 and ABC3 were expressed and located on the plasma membrane of S. cerevisiae.
Quantification of transcript levels of 6 differentially expressed genes located on the chromosomes 1p and 17p13-q21 was performed for 19 infant NB tumours (12 stage 4s and 7 stage 4 < 18m) with available adequate specimens.
The number of differentially expressed genes located on the major autosomal arms or the small heterochromatic fourth chromosome is similar to random expectation (Table 1), and we observed a minor but significant deficit of differentially expressed genes on the X chromosome (17% of genes detected on the array are X-linked, 15% of differentially expressed genes are X-linked; χ test; P = 0.007).
The potential relationships among the differentially expressed genes located on chromosome 11 are illustrated in Supplemental Figure 3. Indeed, these genes (FADD, DAK, RARRES3, FUT4, CD44, and CASP1) have functions related to cell death and appear to be involved in cell defense mechanisms.
66 (40%) out of 168 differentially expressed genes were located on chromosome 1, 73 (43%) on chromosome 2 and 29 (17%) on chromosome 3.
259 out of 550 differentially expressed genes were located on chromosome 1 (47%), 221 (40%) on chromosome 2, 67 (12%) on chromosome 3, and 3 (less than 1%) on the plasmid.
On the other hand, genes, particularly those are highly expressed, are mainly located on the leading strands.
As an example, we found an over-representation of genes expressed in cerebellum located on chromosome 13.
