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It may take millions of years for duplicated loci to resolve to a single locus - however, silencing of duplicated loci such that only a single locus is actively expressed is expected to occur relatively quickly after duplication [ 47, 89- 91].
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That is, acquisition of a highly expressed gene is expected to have a greater fitness effect than that of a lowly expressed gene.
Similarly, gene organization of highly expressed genes is expected to be under stronger purifying selection because the cost of inefficient tuning of expression levels in highly expressed proteins is presumably higher.
As we found that AP genes are more likely to be differentially expressed, it is expected that AP genes are more likely to be involved in disease.
Note that a differentially expressed protein is expected to have a non-zero log2 fold change.
Understanding the patterns of expressed genes is expected to provide insight into disease pathogenic mechanisms, therapy evaluation, or biomarkers for risk prediction.
Although no differentially expressed gene is expected in these experiments, the high variation of the generalised log ratios indicates decreased sensitivity of the measurement if total RNA is compared to aRNA on the same array.
The IFN-I activation in mice infected with the IFNα/βBPGAGmut expressing viruses is expected to enhance T (CD8+, CD4+) and NK cell responses, as shown in mice infected with an ECTV IFNα/βBP mutant23.
Using patient-derived iPSCs to recellularize the decellularized, cadaveric lung scaffolds that lack donor cells expressing alloantigens is expected to generate functionally engineered lungs for "autologous" transplantation.
Differences in the functional context in which particular genes are expressed are to be expected compared to model organisms such as D. melanogaster and even B. mori.
In contrast, sequence variation of reproductive genes preferentially expressed in males is expected to show a high degree of evolutionary divergence [ 55].
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CEO of Professional Science Editing for Scientists @ prosciediting.com