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If activation-associated modifications could always spread over a long distance, many genes would be expressed inappropriately.
However, if our aim is to identify genes that are causally driving aspects of the neoplastic phenotype, then we need to identify those sequences which are expressed inappropriately as a consequence of induced DNA damage or erroneous epigenetic marking.
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This model is supported by genetic data with BMP6−/− [ 19, 20] and liver-specific SMAD4−/− [ 21] mice, which develop iron overload and express inappropriately low hepcidin levels.
It provided a forum for cynics, and due to inexperience, some people expressed themselves inappropriately.
The result is as predictable as it is painful: That which is repressed will still be expressed, just inappropriately.
Globally releasing it could catastrophically affect the pattern of genes expressed by inappropriately activating most genes.
This is plausible in light of findings that in daf-2 mutants, dauer-stage genes are inappropriately expressed in non-dauers [46]; presumably inappropriate repression of non-dauer-stage genes also occurs.
Such inappropriately expressed genes may be detected by microarray or other expression analyses of tumour against normal tissue.
Two weeks ago, a segment of Kansas City fans of indeterminate size inappropriately expressed their frustration with the team's starter, Matt Cassel, by cheering when he was knocked out of a game with a concussion.
Both are essential for robust transcription at steroid hormone regulated genes and both are associated with disease when inappropriately expressed.
Therefore, we chose to develop a mouse model in which TLX1 is inappropriately expressed in immature thymocytes using the doxycycline-regulated transgenic system.
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