Here we report the cloning and characterization of the porcine PKD2 cDNA showing that the full-length gene (3370 bases) is highly expressed in kidney, with minimal expression in the liver.
Glutamyl-aminopeptidase (GAP) (EC. 3.4.11.7) is a zinc metallopeptidase with angiotensinase activity highly expressed in kidney tissues and its expression and activity have been associated wtih tumour development.
Northern blot analysis showed that BICDR-1 is predominantly expressed in kidney and brain, whereas some expression can be seen in testis and heart.
This approach provided a snapshot of proteins expressed in kidney and also differences in protein expression between the normal and the diseased tissues.
In addition to its strong hepatic expression, HNF-4α has also been found to be expressed in kidney, pancreas and the intestine in humans (Wirsing et al. 2011).
Moreover, as reported in the HPRD and Unigene databases, the AF4 transcript is expressed in kidney, and HEK-293 cells have served previously as a heterologous expression system to study mouse recombinant AF4 [ 15].
For example, MT3 gene has been determined as specific to brain tissue but also it is expressed in kidney, renal carcinoma and bladder cancer12,13,14.
We also wanted to verify the hypothesis of whether the protective action of GSH is mediated by products of the extracellular breakdown of GSH catalysed by γ-glutamyl transpeptidase (GGT), an enzyme that is highly expressed in kidney tubular cells.
It is expressed in kidney but not submandibular gland (SMG).
As previously reported, the transgene was expressed in kidney, pancreas, and brain, and the kidney phenotype was characterized by albuminuria and reduced nephron mass.
The mRNA of ATRAP was abundantly expressed in kidney, heart, and testis but was poorly expressed in lung, liver, spleen, and brain.
