The 42 mesothelin highly expressed, high-grade serous adenocarcinoma patients showed a marginally shorter OS than did 17 mesothelin low-expressed patients (13 vs 34 months, P=0.055).
These findings were reproducible in wtEGFR expressing high-grade glioma derived from Singaporean patients.
High-grade gliomas expressed higher level of filamin C mRNA than low-grade gliomas.
Few of the high-grade tumors expressed high levels of PTCH1 in the absence of GLI1 expression and few of them showed high expression in the presence of GLI1 expression.
Interestingly, one of the primary tumor samples collected from a dog with a biologically low-grade MCT expressed high levels of miR-9 and the unsupervised hierarchial clustering of all 24 MCTs demonstrated that this dog's tumor clustered with the biologically high-grade tumors.
Multivariate analysis demonstrated a statistically significant and independent lower risk of death for patients whose tumour expresses a positive TTF1 staining (HR=0.40, 95% CI 0.25 0.65; P<0.0001), and a statistically significant and independent lower risk of death for patients whose tumour expresses higher grade of differentiation (HR=0.64, 95% CI 0.46 0.91; P=0.46 0.91
Although the total number of pediatric gliomas that over-expressed BMI1 mRNA varied depending on the normal references (fetal brain vs. adult brain), the trend remained the same, i.e. high-grade gliomas expressed higher levels of BMI1 mRNA than did low-grade gliomas.
Thus, it is likely that regulators of pluripotency, such as Oct4, are selectively expressed in high grade gliomas as a result of a combinatorial activity of cell autonomous mechanisms and signals emanating from the tumor microenvironment.
MCM5 has been characterized as highly expressed in high grade tumors.
LSD1 was abundantly expressed in high grade DCIS (IRS = 12) compared to intermediate and low grade DCIS.
TGF-α and p-MAPK were more expressed in high grade tumors (p = 0.03058 and p = 0.04 respectively).
