While luciferase activity was clearly observed in all tissues from WR-Luc infected mice, in comparison NYVAC-Luc expresses greatly reduced levels of luciferase.
Prior to differentiation, Tsc2−/− MEFs express greatly elevated levels of both the PPARγ protein (Figure 4E) and transcript (Figure 4F), and these are dependent on elevated mTORC1 signaling, as indicated by their sensitivity to rapamycin.
In murine models, the knockout of Pim-1 results in the inability to reconstitute bone marrow following irradiation, and Pim-1 knockout cells express greatly reduced amounts of CXCR4.
This type of tumour, thought to originate during the defective differentiation of organ precursors (Miereau et al., 1987), often expresses greatly elevated levels of mRNA for IGF-II, a known mitogen for these cells and abundantly expressed in their presumed normal counterparts (Scott et al., 1985; Schofield & Tate, 1987; Gray et al., 1987).
Furthermore, we find that intestinal CD103+ DCs express greatly elevated levels of the TGF-β activating inTGF-β activatingch integrinutely required for both their enhanced ability to activate latent TGF-β and their specialized ability to induce iTregs in vitro and in vivo.
At one of our evaluation committee meetings everyone expressed how greatly they were impressed by the publication record of one of the applicants.
The new approach begins with the assumption, based on the argument just presented; that the general codon usage features observed in highly expressed genes greatly differ from that of randomly generated sequences with their sequence composition conserved.
Previous studies have shown that CLTC is expressed at greatly increased amounts compared to CLTCL1, and so we sought to analyse the comparative amounts of the two genes throughout CNS development.
We identified, for the first time to our knowledge, transcripts for the putative respiratory gene ZMO1814 (rnfA), encoding a putative NADH ubiquinone oxidoreductase subunit that were expressed more greatly (3.3-fold) under aerobic conditions.
When the PCGF1 complex was purified its composition was almost identical to the KDM2B complex, with the exception that it also included RING1A, an alternative catalytic core of PRC1 that is highly sequence-similar to RING1B but is expressed at greatly reduced levels in ESCs.
