Other previously unreported, but potentially interesting targets included the spindle assembly checkpoint genes BUB1 and BUB1B, which were over-expressed; given that APC has a proposed (though controversial) role in chromosomal instability through chromosome mis-segregation, it is possible that BUB1/BUB1B are over-expressed in response to mitotic checkpoint activation (22).
I was taken back to hear the thoughtful responses that the men and women shared and optimism that was expressed given their circumstance.
Nguyen et al. previously reported a transgenic zebrafish model constitutively expressing krasV12; now, they improve on this system by developing a model that allows krasv12 to be inducibly expressed, giving 100% tumour incidence that can be temporally controlled.
For instance, the probability of Gene2 being over-expressed given that Gene1 is over-expressed is 0.7, which may be interpreted as implying Gene1 activates Gene2.
Carlo Cracco, the chef behind the Cracco restaurant in Milan, served as an adviser to Mr. Guadagnino, who calls food "a tool to express the utter giving that a lover can display to the other without words".
Given that highly expressed genes tend to be shorter than and lower expressed genes, we considered the role of genetic-linkage in our study.
Given that PDLSCs expressed higher levels of P2X7R under osteo-inductive conditions and that inflammation decreased P2X7R expression, we further explored whether the regulation of P2X7R in PDLSCs can reverse the impaired PDLSC osteogenesis observed under inflammatory conditions.
Given that fibroblasts expressed LRRK2 protein to levels in excess of those detected in various mouse brain regions, it was concluded that fibroblasts were a useful system to evaluate how the expression of WT and G2019S LRRK2 influenced mitochondrial function.
Given that aberrantly expressed miRNAs vary among different tumour types and some of them are secreted into blood (Mitchell et al, 2008), circulating miRNAs can potentially serve as noninvasive markers for CRC detection.
Given that genes express in pathways, and can be highly correlated, it is perhaps not surprising that even 20-40 sets can yield highly accurate predictions.
