Translational coupling, the interdependence of translational efficiency of genes encoded within the same operon, might also favor similar expression levels for proteins expressed from the same operon (Lovdok et al. 2009).
Although these two VSG genes were expressed from the same VSG expression site, the amount of transcript and protein produced from each VSG appeared to be about half normal levels (Fig. 1C and 1D).
Additionally, expression of aphC and perR genes, both expressed from the same divergent promoter in Synechocystis, is known to be responsive to hydrogen peroxide [ 31, 32].
Alternative splicing not only regulates protein expression, but also allows multiple proteins to be expressed from the same gene resulting in significant proteomic diversity [9].
Previous studies also showed that miR-143 and miR-145, which are expressed from the same precursor [26], showed reduced expression in HPV-induced pre-neoplasic lesions suggesting that they might be involved in cervical carcinogenesis.
Interestingly, the expression of miR-182 which is co-ordinately expressed from the same genetic locus as miR-183 has been shown to be downregulated in ER positive tumors[ 13], this supports our finding of miR-183 dysregulation in association with ER status.
Additionally, different proteins expressed from the same plasmid are presumed to have similar expression levels.
Furthermore, mice derived from independent ES cells clones containing a transgene expressed from the same promoter all exhibit comparable levels of expression [ 2, 4- 6].
This hypothesis appears to hold true as under non-stress conditions and when expressed from the same promoter, there are many differences in the expression levels of a variety of genes between cells expressing different Hsp70-Ssa family members.
Although L4-22K protexpressionsion from Clone A1-L4 was not tested as no specific antibody was available, it would be expected that this protein, which shares the same start site as L4-33KFLAG and is expressed from the same L4 promoter, should resemble L4-33K itsits expression.
We found that two specific microRNAs expressed from the same genetic locus, miR-143 and miR-145, were over-expressed in our invasive subpopulations.
