Exact(15)
GRPR (gastrin-releasing peptide receptor) is a highly expressed factor in pancreas and assists insulin secretion by stimulating the autonomic nerves (Figure 5C [76].
As shown below our study of gene expression kinetics of growth factors showed that BMP-2 was the most rapid and highest expressed factor, followed by BMP-7 and TGF-β1.
And, Oct-1 has been demonstrated as a ubiquitously expressed factor [52].
The methylation status of specific conserved sequences regulates the binding of the ubiquitously expressed factor CTCF to the ICR, which functions as an insulator and enhancer blocker.
TFAP2 is a developmentally regulated, retinoic-acid inducible transcriptional activator [24], while SP1 is a ubiquitously expressed factor that interacts with numerous other transcription regulators involved in many pathways (e.g., HIV-1 Tat, P53, RNAPII, EGR1, TFAP2) [26], [26].
Heat shock induction of HLH-1 during early embryogenesis results in high levels of nuclear-localized protein and widespread conversion of blastomeres to the bodywall muscle fate, demonstrating this over expressed factor is functional and can activate target genes in muscle.
Similar(45)
Moreover, we identify many widely expressed factors that impact transcriptional regulatory networks in a cell-selective manner.
An analysis of expression of the ETS and GATA transcription factors showed that Erg, Fli-1 and GATA-2 are the most highly expressed factors in endothelial cells.
Thus we hypothesise that Htl acts in cooperation with Wg to induce Lbe and with some dorsally expressed factors to activate Duf.
The differentially expressed factors included IL-8, IL-16, TNF-α, GM-CSF, MCP-2, TGF-β, and IP-10.
In contrast to SCNT, reprogramming with exogenously expressed factors is inefficient and requires multiple cell cycles to achieve pluripotency.
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