BCBL1 cells express extremely low levels of endogenous K13 [40], [40], and demonstrate weak NF-κB activity as compared to the BC1 and BC3 PEL cell lines (Figure S1).
We found that both types of cells express extremely low levels of AR mRNA and protein and neither cell type responded to DHT treatment after transfection with an androgen-responsive luciferase reporter vector so neither is likely a good model for studying androgen regulated gene expression.
c12 cells are c7 derivatives that express extremely low levels of AhR (Zhang et al. 1996).
Most of the human pancreatic tumour cell lines were found to be HER-4 negative while expressing extremely low or undetectable levels of HER-3 (Table 1).
Differentiated neuroblastoma cell line SHSY-5Y was reported to express extremely low (∼17) EpoR homodimers on the cell surface (Um et al, 2007).
Moreover, the induction of the mTOR pathway was evaluated in FB-1, human anaplastic thyroid cells, expressing extremely low levels of CXCR4 and CXCR7 and in CEM, human lymphoblastic T cells, expressing extremely high level of CXCR4 and low CXCR7.
Several of the laboratory strains derived through the Castle lineage express extremely low and sometimes undetectable levels of darcin [ 22], with BALB/c males expressing darcin at < 0.5% of their total MUP output.
It is noteworthy that most stroma-independent MM cell lines, which typically exhibit phenotypes of very high proliferation and survival, express extremely low levels of BTK and their growth in immunodeficient animal models is often not restricted to the bone.
