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We further excluded expression probes that were deemed not to be expressed, defined as an expression level of less than 50.
Seven proteins were differentially expressed (defined as at least 1.5-fold upregulated or 0.5-fold downregulated) in samples treated with ATRA for 24 hours (Table 1) and 5 proteins were differentially expressed in samples treated for 9 days (Table 2).
We found that the LIV0APOLY cell line expressed defined hepatocyte markers, such as albumin and CK18 (26, 26, 32, 54).
Genes that were differentially expressed, defined as at least a 2-fold change between sham and ischaemic conditions with P<0.05, were used for the analysis.
Another 33.8% of signatures were constantly expressed, defined by Meyers et al. (2004) [ 24] as those signatures with a summed abundance within a two-fold range (expression ratio <2).
Furthermore, the identification of 28 protein-coding genes, detected in this and three previous microarray studies as differentially expressed, defined a core set of proteins involved in the iron-stress response.
Similar(54)
In the present report, several recombinant strains of Salmonella enterica serovar Typhimurium, engineered to express defined murine cytokines, were used to study their potential immunoregulatory capacity in the mouse model of typhoid fever.
The outcome suggests that the adenovirus expressing defined epitopes induced a strong immune response against the peptides, but this response was not sufficient to confer protection against PRRSV challenge.
This result provides proof of concept toward generation of transgenic P. berghei parasites expressing defined regions of PfEMP1 as a tool for in vivo studies of PfEMP1-associated pathogenesis.
Alternatively, transfer of immune cells engineered to express defined T cell receptors (TCRs) and chimeric antigen receptors (CARs) has shown its potential.
The reversion of somatic cell fate to a naїve pluripotent state by expressing defined sets of transcription factors is a major scientific advance with implications at multiple levels [ 11].
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