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BAG3 was found highly expressed, compared with normal human cells or tissue, in many solid tumors, such as HCC [ 10], nonsmall cell lung cancer [ 8], thyroid carcinoma [ 9], pancreatic cancer [ 20], glioblastoma [ 21], and colorectal carcinomas [ 22].
IMP2 strongly correlated with α-fetoprotein (AFP) as a marker of poor prognosis (R=0.63; P<2.2e−16), which was also differentially expressed compared with normal tissue (P<2.2e−16).
In skeletal muscle fibres from patients with muscular dystrophies, inflammatory myopathies, rhabdomyolysis and neurogenic atrophy, CD was found highly expressed, compared with normal skeletal muscle, and it was dispersed in the cytoplasm rather than concentrated in peri-nuclear vesicles as in normal skeletal fibres [ 12].
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In CRC tissue, various miRNAs have been found differentially expressed compared with matched normal tissue (Liu and Chen, 2010; Schee et al, 2010; Dong et al, 2011; Hrasovec and Glavac, 2012).
Pharyngeal squamous cell carcinoma exhibited 38 differentially expressed miRNAs compared with normal pharyngeal epithelium.
Survivin was most highly expressed when compared with normal cerebellar tissue.
Tumors arising in the presence of HBsAg alone led to the lowest number of differentially expressed genes (compared with normal livers), as opposed to those induced by AFB1 (203 versus 381 genes) (Fig. 6A).
About 25% of the genes differentially expressed upon KIAA1199 overexpression were also significantly differentially expressed in adenocarcinomas compared with normal mucosas, indicating a potential regulatory role for KIAA1199 in vivo.
Moreover it has been hypothesized that the Tregs cell homing in sites of infection may be driven by the chemokine receptor CCR5 that is described to be preferentially expressed by Tregs compared with normal CD4+ T cells [32].
Changes in the profile of TNC isoforms expressed in tumours compared with normal tissue have been described.
(Hugo et al 2012) In fact, colon cancer cell lines used in this study barely expressed IL-6 compared with normal fibroblasts.
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