At HH34, SOX2 was strongly expressed by supporting cells, whereas B-RAF was expressed strongly in the macula sacculi, limiting the region of SOX2 expression and suggesting that B-RAF is expressed by hair cells (Figure 2, q t).
It would have added to the paper if the authors had asked whether NT-3 expressed by supporting cells was essential for synaptic regeneration by simply performing the same experiment in their NT-3flox mice.
Using cell-specific and inducible knockout or overexpression technology, the authors demonstrate that NT-3 and BDNF expressed by supporting cells are required for the maintenance of ribbon synapses, a role distinct from that played during embryogenesis.
These observations support the conclusion that endogenous Ntf3 expressed by postnatal supporting cells, but not inner hair cells, is necessary for normal cochlear function.
In the postnatal vestibular epithelia, Bdnf is expressed only by supporting cells (Schecterson and Bothwell, 1994; Montcouquiol et al., 1998), whereas Ntf3 is expressed by both supporting cells and hair cells (Farinas et al., 1994).
One of the concerns expressed by people supporting it is that by requiring users to have a Google+ profile the firm was taking away their anonymity.
The optimal inputs and motion paths are obtained, as Figure 17 shown, where the straight motion paths are expressed by the real support triangles.
The resentments expressed by voters who support Donald Trump, as well as Bernie Sanders, may be misplaced--as Marc Andreessen suggests--but the practical reality is that in a democracy a disaffected majority has every right to upend the status quo, even if they don't actually have a better solution in mind.
GP01 A related approach, expressed by another GP, supported patient debating of pros and cons to solutions that had been offered by the doctor, but not generated by the patient.
The centres (in 48 dimensions) of these four classes are established and an index calculated that measures the level of support expressed by these centres relative to the mean level of support for that e-petition.
