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In particular, bone morphogenetic protein (BMP) 7 showed an inverse correlation between DNA methylation and expression in human BPD samples, with BMP7 being expressed at reduced levels in BPD.
Except for Gsts, which were expressed at reduced levels, fasting had no denoting effect on expression of phase II metabolism genes.
A type of allele from which either the gene product is expressed at reduced levels relative to the WT or the gene product displays a reduced level of activity.
We show the OR43b gene on the balancer chromosome SM5 is expressed at reduced levels and contains nucleotide polymorphisms predicted to alter two amino acids in the receptor, including an arginine128 to proline substitution in the first extracellular loop.
In contrast, rod and cone-specific genes involved in phototransduction including rhodopsin (RHO), G protein subunit alpha transducin 2 (cone transducin, GNAT2) and rod phosphodiesterase 6A (PDE6A) showed the opposite trend and seemed to be expressed at reduced levels in the aged retina.
For instance, Lefty1 and Stella (also known as Dppa3), expressed at reduced levels in pES cells C3, compared with pES 1116 or ES cells.
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Transfection of these constructs in MCF7, HeLa and the p27-negative GH3 pituitary adenoma cells confirmed the expression of the fusion proteins in vitro and showed that p27P69L is consistently expressed at reduced level compared to p27wt in all cell lines (Fig. 1B).
In comparison, only 34 of 150 are expressed at reduced level in FC RPE when compared with adult native RPE.
Four cytokines were consistently found to be expressed at reduced level in the serum of MIF−/− growing B16-F10 tumours.
This goes beyond the low expression level of p27P69L in vitro and suggests that both the wt and mutant allele are expressed at reduced level.
We show that p27P69L is expressed at reduced level and is impaired in both binding to Cdk2 and inhibiting cell growth.
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CEO of Professional Science Editing for Scientists @ prosciediting.com