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ASCL1 mRNA and protein was detectable in all NB cell lines tested but was found to be expressed at differing levels (Fig. 4C,D).
In particular, we found that alleles of several hemoglobin-related genes, including the adult beta globins and transferrin, were expressed at differing levels between the strains at early stages of the fetal-to-adult hemoglobin transition, but then equalize by the end of our developmental time course.
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On a global scale, we determined how the H3K4me3/H3K27me3 ratio differed at bivalent genes known to be expressed at different levels in ES cells.
We found that P100 is expressed at different levels in the tissues of the developing mouse and its relative level to CTF also appears to differ among the tissues (Figure 1E).
These genes are expressed at different levels.
Adar1; Mavs E15.5 fetal livers appear normal and comparisons of RNA sequencing (RNA-seq) data from Adar1; Mavs and Mavs livers could not identify any protein-coding transcripts expressed at significantly differing levels.
Hence PKD1 and PKD2 are co-expressed in many adult tissues, albeit at differing levels, but one exception is in lymphoid cells, which appear to only express PKD2.
As shown in Fig. 2, all the hypothesized paths are significant at differing levels.
Macaques may encode as many as 30 distinct MHC class I transcripts expressed at widely differing steady state levels in peripheral blood.
We found that 18 of the 23 genes were expressed at low levels and that their expression levels did not differ between the two species.
In contrast to the microarray results, ATM was expressed at lower levels in B35-positive HCs, but its expression did not differ in B35-positive and B35-negative lcSSc samples (Fig. 5c).
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