As observed by Laudencia-Chingcuanco et al. [ 33] during a transcriptional study of wheat grain, genes highly expressed at a particular stage may indicate their relevance to stage-specific developmental functions.
Only 2 7% of these pairs included paralogs that both had a unique expression profile wherein one paralog is expressed at a developmental stage or a tissue type where the other one is not expressed, and vice versa (Fig. 3).
For example, if a common major regulator of a set of target genes is not expressed at a given stage, the expression of target genes will then be controlled by other factors that are not necessarily shared between all the genes, giving rise to divergent expression patterns at a particular stage.
Genes that were identified as being expressed at a single stage of the asexual cell cycle (either ring, trophozoite, or schizont stage) and that were expressed at relatively low levels at the gametocyte stage (bottom 70% expression levels of all genes) were included in the stage-specific expression groups.
Genome wide expression analysis will provide information on the genes that are expressed at a specific stage of development or in a particular condition while the whole genome sequence provides comprehensive information on the total number of genes present in an organism.
We show here that HOP is expressed at a precise stage of epidermoid cell differentiation and its expression is lost in HNSSC, suggesting that HOP may be a general tumour suppressor gene involved in keratinocyte differentiation.
If a mouse gene is expressed at a given stage, we assumed the same activity of the human homologue (Figure 8).
The SGZ contains neurons in various stages of neurogenesis and a large number of SGZ neurons expressed stathmin1, suggesting that it is expressed at a specific stage of neurogenesis.
Core-binding factor, alfa subunit 1/runt-related transcription factor 2 (CBFandRUNX2) and osterix (OSX) are transcription factors that play a crucial role in osteoblast differentiation, and ALP is an enzyme expressed at a later stage being involved in bone matrix maintenance.
Second, mpz may be expressed at a later stage in zebrafish development, due to gene regulation by other elements (e.g., silencers) acting in a concerted fashion with the intron-1 enhancer.
