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Interestingly, of the 46 inappropriately reprogrammed genes in SRCB, 19 were expressed at a normal levels in SR3 (Table 2).
For example, the helix-loop-helix factor E2A is expressed at a normal level, while EBF1 and Pax5 are both upregulated (Fig. 6).
ISCU proteins in these patients are expressed at a normal level, but they are nonfunctional.
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We can infer that some genes which suffered hypermethylation in the abnormal cloned group don't express at a normal level.
Amplification of ANO1 in breast cancer was correlated with disease grade and poor prognosis 7. Using the Oncomine database to determine the expression of ANO1 in normal and malignant tissues from a variety of tumor types, the Duvvuri group found that although ANO1 may be expressed at a high level in normal breast tissue, its expression is even higher in neoplastic breast tissue.
When these cells underwent growth arrest and differentiated into polarized acini, EphA2 levels were significantly decreased [ 15], consistent with the observation that EphA2 is expressed at a low level in normal mammary gland epithelium, whereas expression increases in breast cancer [ 3].
Although G9a's two protein isoforms are expressed at a low level in normal DRG, they can be activated at the transcriptional level.
RAET1G1 was expressed at a low level in normal gastrointestinal epithelial cells in a similar pattern to MICA.
MicroRNA-205 is expressed at a high level in normal tissue containing squamous epithelium [ 64].
The rules implied that gene 41755_at is expressed at a low level in normal samples.
These results suggest that GPR124 is only expressed at a low level in normal tissue and is absent or at a very low level in cultured endothelial cells.
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