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For the simpler model, including one kind of benefit and one kind of harm, the individualised ARR required to justify treatment was expressed as required ARRtarget(i =ARIharm(i) × RVharm/target(i).
If chromatin is in the condensed conformation, transcription factors cannot access the DNA and genes are therefore not expressed, whereas genes in open chromatin can be expressed as required.
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In non-inferiority trials, the CID for a patient can be expressed as the required reduction of the harm which exactly compensates for the allowed increase of the target outcome, value-adjusted.
Results are expressed as number (percentage) or median (Interquartile range), as required.
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