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None of them is expressed appreciably in normal skin.
We first determined that both p110α and p110β are expressed at the mRNA and protein level in C2C12 myoblasts, but that p110γ and p110δ were not expressed appreciably.
Interestingly, in all three genes where this occurred the short isoform was expressed well in all tissues while the long isoform was only expressed appreciably in the two neural tissues [ 10].
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Whereas lysosomes in non-neuronal cells were distended by a massive accumulation of a set of sphingolipids due to multiple sphingolipid hydrolase insufficiency, due to pSap deficiency, leading to the foamy appearance of the affected cells, the neurons expressed an appreciably different pathology.
We also included genomic regions covering the genes for CYP4A22 and most of CYP4AZ1 located downstream of MAP17, which are not appreciably expressed during haematopoiesis [14].
Unexpectedly, R1441C-LRRK2 mRNA expression is detected at highest levels in the cerebral cortex and cerebellum but is not appreciably expressed in the striatum, hippocampus or ventral midbrain of transgenic mice (Figure 2A B).
To confirm that Bcl-x is appreciably expressed at the protein level during islet tumorigenesis, we went on to assess the levels of Bcl-x protein by Western blotting using lysates from normal islets and from the discrete stages of pancreatic islet tumorigenesis in RIP1-Tag2 mice.
Other SK channels were not appreciably expressed in AGRP neurons.
The third gene, MdTOM7.1 was not appreciably expressed in response to drought treatment.
Furin was coexpressed with β-hCG in STB, whereas neither furin nor β-hCG was appreciably expressed in CTBs.
These genes were all appreciably expressed in Mb and Mt samples (Fig. 4E; Fig. S3; Table S1) and skeletal muscle.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com