Sentence examples for expressed aid from inspiring English sources
This study shows how candidate molecules that were differentially expressed, aid in designing targeted therapy against the two phenotypes of PCOS.
We observed that B cells exposed to HIVNL4-3 expressed AID, at a level approximately 35% of that seen in B cells stimulated with agonistic anti-CD40+IL-4, wasch was used as a positive control (Figure 1).
The majority of B cells that expressed AID following exposure to CD40L-positive HIV also expressed CD71: 94±4.4% of AID+ B cells exposed to CD40L-positive HIVNL4-3 supernatants co-expressed CD71.
Factors interacting with AID might also be needed to restrict the mutator activity of AID to the immunoglobulin loci and protect genome integrity: For example, constitutively expressed AID leads to T cell lymphomas and lung micro-adenomas in transgenic mice [9], and AID expression has been linked to oncogenic translocations [10], [11] and inflammation-associated cancer [12] [14].
We first analyzed the in vivo mutagenic activity of ectopically expressed AID.
As with the human tumor cells, mouse primary epithelial cells expressed AID upon exposure to TNF-α (Fig 1C).
The positivity of epithelial markers (pancytokeratin, CK7, CK18, and EMA), although weakly expressed, aids in the ability to distinguish these tumors from lymphomas, melanomas, or sarcomas.
Here we show that when using non-replicative episomal vectors containing a GFP gene, inactivated by the introduction of stop codons at various positions, a high level of EGFP positive cells was obtained after transient expression in Jurkat cells constitutively expressing AID.
Concomitantly, a recent report showed that CLL samples expressing AID transcripts harbored significantly more γ-H2AX foci than non-AID-expressing samples when dsDNA repair by homologous recombination is inhibited, indicating AID-induced DNA damage [46].
The origin of these mutated B cells is unknown; the IgMIgDCD27 cells do not express AID and appear to acquire mutations independent of stringent selection by Ag.
Here, we demonstrate that immature/transitional 1 B cells from the bone marrow of CD154-deficient mice express AID and acquire Ig mutations that lack the hallmarks of antigenic selection via BCR signaling.
