Additionally, metabolically active bacteria can express a substantial amount of therapeutic molecules and continuously release them during infection.
The muscles presented in figure 2 express a substantial amount of GFP- fusion protein resulting in accumulation of GFP in most nuclei.
However, Koukouritaki et al. and others demonstrated that CYP2C maturation depends only on postnatal age and 51% of newborns exhibiting values close to mature levels suggesting that the most immature neonates could express a substantial amount of CYP [24].
In fact, the peripheral blood cells from RA patients fail to express a substantial amount of normal hRasGRP4 protein.
Several cancers, including colon cancer, breast cancer and osteosarcoma, are known to produce S100A4 [ 10], and particularly, HT29 cells have been described to express a substantial amount of S100A4 [ 21].
Cultured human astrocytes expressed constitutively a substantial amount of AQP1 protein with a molecular weight of 28-kDa, which represents the non-glycosylated form (Fig. 5a, lanes 1, 4, 6).
In parallel tests of plants under long days or short days, the RfBP gene was highly expressed and a substantial amount of the RfBP protein was produced in leaves of RfBP+ in contrast to the absence of gene expression and protein production in the WT plant.
We did not observe hyperplasia in the intestinal tract although CK19CreERT is widely expressed in this mucosa [17] and a substantial amount of recombination of the KrasG12D allele was seen (Figure 8).
Interestingly, we found that high levels of ubiquitously expressed WT lysozyme are lethal during metamorphosis, as revealed by the failure of a substantial amount of the pupae expressing the protein to reach maturity and eclose.
As demonstrated in Figure 8 using two representative tumors, maspin was absent or expressed at a very low level in a majority of tumors in animals fed either a control (corn oil) or DHA diet; however, a substantial amount of maspin was expressed in tumors from mice fed a CCM diet, and its expression was further stimulated in tumors from DHA + CCM fed animals.
