CC cell lines express a pattern of different growth receptors in vitro.
However, a subset of RA patients has been shown to express a pattern of genes that reflects the contribution made by IFN-α [ 13].
Clinical studies have shown that major depressive patients express a pattern of anti-inflammatory cytokines, in association with high cortisol levels [ 9, 10], which might reflect immunosuppression.
Immunohistochemical analysis revealed that topoisomerase II beta was widely distributed ( > 90% positive tumour cells), but that topoisomerase II alpha expression was less widely expressed, with a pattern of expression similar to that of the proliferation-dependent antigen recognised by Ki67.
The gene network that controls development includes the 'pair-rule genes' that are expressed in a pattern of alternating stripes that wrap around, top to bottom, along most of the length of the embryo.
Lymphoma cells from ascitic fluid were cultured on a human embryo fibroblast feeder layer and, after a short lag period, a cell line (DH-BL) was established which, like the original tumour, was both negative for the Epstein-Barr nuclear antigen (EBNA) and expressed a monoclonal pattern of surface immunoglobulin (alpha lambda).
Each adult mouse expresses a pattern of 8 14 different MUP isoforms in its urine, which is determined by its genotype and by its sex because some MUP genes show sex-limited expression (Hurst 2009).
Monocytes isolated from HIV infected patients expressed an altered pattern of nuclear receptors characterized by a profound reduction in the expressions of FXR, PXR, PPARα, GR, RARα and RXR.
Interestingly, not only are group members co-expressed, in many cases they show a pattern of phenotypic redundancy where severe developmental defects are only observed when multiple members of the same group are removed [ 27, 37- 43].
