Recently a "functional proteomics" study showed that stressed squamous cells do not synthesize the classic stressed-induced protein HSP70 [9], but instead express a novel class of stress proteins [10], including the Squamous Epithelial induced stress Protein of 53 kDa (SEP53; synonyms include c1orf10 and cornulin).
Our findings suggest that complement receptors C3aR and C5aR expressed on CD8+ tumor infiltrating lymphocytes represent a novel class of immune checkpoints that needs to be targeted for tumor immunotherapy.
SNORD116 belong to a novel class of snoRNAs, expressed most highly in brain in humans and exclusively in brain in mouse.
Further analysis has revealed a distinct signature for these mature-sperm-enriched small RNAs, which represent a novel class of abundantly expressed small RNAs that can be grouped into distinct families.
Among human diseases, it has been shown that miRNAs are aberrantly expressed or mutated in cancer, suggesting that they may function as a novel class of oncogenes or tumor suppressor genes 3.
Three Gαs genes have been identified in the zebrafish genome, and a fourth gene belonging to a novel class of G alpha subunit, gnav1, is expressed in the inner ear (Oka et al., 2009).
The selective inducers of apoptosis in ras-dependent cells could represent a novel class of cancer chemotherapeutics useful for treating tumors expressing constitutively active, mutant ras.
Zhao et al. (2010) identified a novel class of SKP-1-like proteins, PhSSK1, in P. hybrida, which is expressed specifically in pollen and might act as an adapter in the SCF complex.
The maize genome encodes and expresses at least five different SUN-domain proteins, of which the PM3 subfamily may represent a novel class of proteins with possible new and intriguing roles within the plant nuclear envelope.
In the proposed approach the data stream will be either classified into an existing class or into a novel class.
