Unsettling still was the fact that while cancer cells could express a multitude of new and unknown antigens as a result of malignant transformation, the immune system was not stimulated to target these antigens/cells.
It is probable that within a large clump (Figure 1A); individual cells experience different micro-environmental conditions and thus express a multitude of different physiologies and growth behaviors [42].
While not previously reported, it is logical that in the context of cancer cells, which are known to express a multitude of activated kinases, the steady state of vimentin will be shifted toward the presence of a large pool of free, depolymerized "activated" vimentin.
57 Additionally, GBM cells express a multitude of immunosuppressive molecules, preventing the anti-tumor activity of leukocytes.
1– 7 Therefore, the different layers of skin express a multitude of enzymes involved in lipid metabolism, including lipid hydrolases, sphingomyelinases, lipases and desaturases.
Other examples of species that express a multitude of PPs are the locusts, Schistocerca gregaria and Locusta migratoria (7 and 4 known PPs, respectively).
While affected joints express a multitude of inflammatory mediators, systemic inhibition of TNFα turned out to be a particularly successful therapeutic strategy [ 60– 60].
Older persons often express a multitude of problems due to age-associated changes, making the diagnosis of depression particularly difficult [ 63 ].
Biochemical and molecular studies amply demonstrated that plants express a multitude of carbohydrate-binding proteins (also called lectins or agglutinins) [ 1, 2].
Instead of a dichotomy between residency and anadromy, steelhead express a multitude of different, independent life histories, including sexual maturity as a resident at a variety of different ages or smolting at a variety of different ages.
