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While not all subsets of BCP-ALL cells express surface pre-BCR, most express components of the pre-BCR intracellularly.
In this phenotype, microglia express surface molecules and secrete soluble factors, which influence astrocytes and neuron function [50], promote the clearance of cellular debris and aggregated proteins [51].
The cells of follicular lymphomas express surface immunoglobulin, more frequently IgM +/− IgD > IgG > IgA, B-cell-associated antigens, CD10+/−; they are CD5−, CD23−/+, CD43−, and CD11c−.
These results suggest that monocytes express surface ERBB3.
Thus our results establish that mouse Foxp3+ Tregs do express surface LAP.
Human FOXP3+ Tregs have also been shown to express surface LAP [15], [16], [17].
We tested whether unstimulated CD4 T cells also express surface LAP using the direct conjugates.
Unlike humans and macaques, the majority of NKT cells in sooty mangabeys did not express surface CCR5.
Removal of IL-7 promotes maturation of the cultured pro/pre-B cells into immature B cells which express surface IgM [51] and κLC on their cell surface.
We also confirmed that Foxp3+ Tregs express surface LAP/TGF-β by using our newly developed anti-mouse LAP/TGF-β mAbs [14].
It should be noted that MBEC did not express surface HER2 in contrast to CRL-5904 and BT-474 HER2-postive tumor cell lines used (Figure 2b).
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