As is ubiquitously expressed, we speculate that endogenous ouabain has a developmental role in modulating cell cycle progression.
By Monday, the Scottish Daily Express was speculating that former Ranger Kenny Miller – last seen whiffing a Carling Cup game-winner on behalf of Cardiff City – might be bound for Portland.
While it was unclear whether the mutant protein is actually expressed, we speculated that due to the frameshift, any mutant protein produced will contain 61 altered amino acids.
Given that we observed tamoxifen/OHT-independent Cre activity in several high expressing clones, we speculate that this phenomenon is an intrinsic property of mCrem in DT40 cells, possibly because of their small cytoplasmic volume, which may encourage mCrem nuclear translocation as expression increases.
Other studies have shown that osteoclasts, as well as CFU-M lineage macrophages, express CD68, and we speculate that the CD68-positive mononuclear cells within the granuloma represent the precursors for the osteoclast-like cells involved in the resorptive process at the bone surface.
The majority of cDCs in the healthy SI also express CD103 and can be similarly divided into two subsets 24, a major population of SIRPα+ IRF4-expressing cDCs that we speculate are equivalent to murine intestinal CD103+CD11b+ DCs, and a minor population of CD141+ cDCs that are likely equivalents of CD103+CD11b− DCs 86– 86.
Since our shRNA vectors were designed to selectively target liver cells, and since in the spleen SR-BI is mainly expressed in monocytes/macrophages, we speculate that the observed upregulation of SR-BI in spleen might be due to decreased loading of macrophages with apoB-containing lipoproteins.
Instead, the eyes might express intensity, he speculates.
We can raise an index of suspicion, make back-seat observations of someone's behavior to express our concerns and even speculate as to whether illness may be the underlying cause.
Given that small subsets of adipocyte progenitors in WAT express myf5 [ 12], we speculate that loss of Atg7 in a pool of eWAT-resident Myf5+ cells impacted 'Beige' cell development in eWAT, while 'Beige' cells in iWAT possibly originate from redundant lineages and thus remained intact.
