Monitoring of Luciferase expression in individual mice from the F1 cohort revealed that all Mycl1 expressing tumors initiated around the same time point and showed identical growth leftacteristics, making this model very suitable for tumor intervention studies (Fig 4E).
Whether or not this type of mechanism is effective depends on the size of the cost investors incur when they express demands, initiate protests, or organize appeals (any method by which they try to protect their legal rights).
We found that none of the transgenic males expressing ChR2 initiated ejaculation or released sperm upon stimulation.
Genes in cluster a show high levels of conjugation-specific expression and, once expression is initiated, are expressed for long periods.
This same situation may apply to the RNA polymerase II transcribed genes that constitute the basal transcription machinery, which may need to be rapidly and highly expressed to initiate a general transcriptional increase in ring stage.
Xist coats the X chromosome from which it is expressed and initiates a cascade of events including exclusion of RNA polymerase II, changes in histone marks, and recruitment of structural chromosome proteins [ 1– 3].
Here, we demonstrate that the U6 promoter from a lepidopteran model insect, Bombyx mori, effectively expressed the sgRNA initiated with any nucleotide bases (adenine, thymine, guanine or cytosine), which further expands the CRISPR targeting space.
Cytokinins negatively regulate the initiation of crown and lateral roots in rice (Rani Debi et al. [2005]; Kitomi et al. [2011]), but plants that constitutively express CRL5 can initiate crown roots normally.
Injection of an adenovirus expressing FlpO recombinase initiated primary soft-tissue sarcomas and lung adenocarcinomas after as little as 8 weeks.
At puberty the ends of the ducts swell to form the proliferative terminal end-buds, which strongly express brca1 and initiate rapid ductal branching and elongation to the margins of the fat pad.
Our observations and analysis provide information on the temporal order of events with respect to Bra induction, β-catenin signalling and the EMT: (a) cells increase the β-catenin transcriptional activity, (b) cells express Bra and initiate the EMT event and (c) cells reduce transcriptional activity of β-catenin and Bra as cells migrate away from the colony and become motile.
