Sentence examples for express dysfunctional from inspiring English sources

Previous reviews have reported that greater than 30% of human tumors have elevated expression of Pol β [1] or express dysfunctional Pol β proteins [2].

BPL cells express dysfunctional CD22, a principal negative regulator of B cell receptor signaling, due to homozygous intronic mutations.

We have demonstrated that recombinant human PLCζ can phenotypically rescue failed activation in oocytes that express dysfunctional PLCζ, and that this intervention culminates in efficient blastocyst formation.

Evidence from an intratibial bone metastasis model indicates that when highly aggressive metastatic MDA-MB-231 cells express dysfunctional Runx2 or small hair-pin RNA for Runx2, both osteoclastogenesis and osteolytic lesions decrease [ 40].

However, a direct relationship between altered gene expression and the phenotypic changes of cells expressing dysfunctional prelamin A has not been established.

Most strikingly, Syo1 overexpression completely restores growth of yeast cells expressing dysfunctional and even lethal Rpl5 variants, which notably harbor single mutations in the globular domain.

In fact, Adcy5 null mice express a dysfunctional motor phenotype consistent with a disruption in striatal dopamine signaling [ 17].

BPL cells express a dysfunctional CD22 due to deletion of Exon 12 (CD22ΔE12) arising from a splicing defect associated with homozygous intronic mutations (Uckun et al., 2010).

Such a scenario would imply that breast cancers having this phenotype express a dysfunctional ERα protein that can nevertheless be detected by IHC.

Cot/Tpl2 KO mice crossed with Apc min/+ mice, which express a dysfunctional truncated Apc protein without sufficient tumor suppressive functions, formed more aggressive colon tumors compared with control Apc min/+ mice.

Finally, when we studied the response to 100 μM resveratrol of human HT29 colon carcinoma cells expressing the dysfunctional p53-273H mutant, HT29 like HCT116 cells showed co-localization of Bax with mitochondria and underwent apoptotic cell death upon drug treatment (data not shown), demonstrating that this effect is not limited to one cell line and is indeed wild-type p53 independent.