Taken together, the presence of increased motor activity not only in ADHD children but also in their non-affected siblings indicates that the QbTest Hyperactivity factor fulfills two important criteria for an intermediate phenotype measure [ 24]: it co-occurred with the disorder and it was manifest in individuals who carry genes for ADHD but do not express the disorder itself.
Because TRN neurons express several disorder-relevant genes identified through genome-wide association studies, exploring the consequences of different TRN disruptions may be of broad translational significance.
Mozart, as composer and pianist, brought the practice to its peak; one of his contemporaries stated that cadenzas should be dreamlike in their logic, expressing "ordered disorder," and Mozart's playing evidently had that quality.
A lot of myths tended to fall apart after World War II, and photographers expressed the disorder in the mid-50's before many were prepared to acknowledge it.
Our results demonstrate that first-degree relatives of ADHD probands, while not behaviorally expressing the disorder, have similar neurocognitive deficits as their ADHD relatives.
"I see many patients that are overly concerned with the quality of their food, and that's the way they express their eating disorder," he said.
Persons with passive-aggressive personality disorder express their hostility through such indirect means as stubbornness, procrastination, inefficiency, and forgetfulness.
This individual design of the instrument ensures Beaton et al [ 32] recommendations that outcome measures should allow patients to generate their own item content to express how the disorder affects them and could be a reason for the high responsiveness found in the present study.
A constitutively expressed, largely disordered IDP with an amino acid composition promoting intrinsic coil conformations and conservation of both primary and disorder sequence is likely to be a ribosomal protein or part of another rigid multisubunit complex.
I will discuss new data arising from the analysis of mouse mutant models expressing developmental disorders and susceptibility to cancer.
