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Added research on the potential for additive or multiplicative interactions between exposures to multiple environmental agents on male reproduction is also needed.
The tools provide a useful approach for assessing risks associated with combined exposures to multiple chemicals.
A decision tree has been developed for evaluating risks posed by combined exposures to multiple chemicals.
Figure 1 WHO/IPCS framework for assessing combined exposures to multiple chemicals from multiple sources [[1]].
where MHQ is the maximum of the HQ values calculated for an individual's exposures to multiple chemicals.
Maximum Cumulative Ratio: The toxicity from the combined exposures to multiple chemicals divided the maximum toxicity from any one chemical.
These people tend to be most vulnerable and have multiple exposures to multiple simultaneous threats (Kelman et al. 2015).
The decision tree can be helpful for prioritization in assessing and managing risks associated with combined exposures to multiple chemicals.
In response to this concern, a number of organizations have investigated the issue of combined exposures to multiple chemicals [1 5].
This paper applies the decision tree to real-world examples of exposures to multiple chemicals, evaluates the usefulness of the approach, and identifies issues arising from the application.
The decision tree described in this paper can be used as a helpful tool for conducting assessments of the risks from combined exposures to multiple chemicals.
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