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While most of the physiological malfunctions occurred following parr exposures to concentrations ≥120 μg Cr l−1, nuclear DNA damage followed exposures to 24 μg Cr l−1, which was the smallest concentration tested.
Metabolism via the primary pathway, postulated to involve alcohol dehydrogenase, is swamped by exposures to concentrations exceeding 220 ppm.
Repeated exposures to concentrations above this NOAEC resulting in prolonged nerve stimulation (within hours) that might occur in working environments can trigger a response cascade leading to chronic adverse health effects.
Bunch et al. (2013), however, found that shale gas production activities did not result in community-wide exposures to concentrations of VOCs at levels that would pose a health concern.
The intersex condition has been recorded in various fish species following exposures to concentrations as low as 10 ng/L each for estradiol and estrone, (Metcalfe et al. 2001; Tabata et al. 2001) and 4 ng/L for ethinylestradiol (Länge et al. 2001).
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Exposure to concentrations of 200 500 parts of hydrogen cyanide per 1,000,000 parts of air for 30 minutes is also usually fatal.
MWCNT-treated cells showed no cytotoxicity after exposure to concentrations between 3.13 and 50 mg CNT/L (data not shown).
A growth delay was measured after 48 h of exposure to concentrations of DWCNTs ranging from 1 mg L−1 (∼29%) to 50 mg L−1 (∼84%).
The decreased effect of SO2 on Ananas comosus is corroborated by experiments performed by Olszyk et al. ([1987]), which showed no effect of acute exposure to concentrations of 0.6 3 ppm over 2 8 hour durations or chronic exposure to concentrations of 0.35 0.9 ppm over 7 13 days.
The aim of repeat dosing should be to optimize the duration of drug exposure to concentrations above the minimum inhibitory concentration (MIC), rather than to aim at higher peak levels.
Our associations were reported with exposure to concentrations of PM2.5 as low as only a few micrograms per cubic meter.
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