Sentence examples for exposures of rapamycin from inspiring English sources

In summary, translationally relevant exposures of rapamycin were achieved in dogs with cancer (Figure 3).

All exposures of rapamycin evaluated resulted in downward modulation of phosphorylation of the mTOR target S6RP in tumors and PBMCs.

Furthermore modulation of traditional PD biomarkers such as phospho-S6RP, as found in this study, is unlikely to define clinically relevant exposures of rapamycin or rapalogs.

The study design was a dose escalation approach (Table 1: Dose Escalation Cohorts and Table 2: Study Schedule) to define relevant exposures of rapamycin and/or maximally tolerated dose (MTD) in dogs with appendicular osteosarcoma.

In 9 tumor samples that passed quality control assessments for ECL there was no post treatment up-regulation of relative p/tAKT (S473) after 8 days of exposure to rapamycin (p = 0.069).

Inhibition of S6RP phosphorylation was a highly sensitive marker of exposure to rapamycin, even in the lowest dose cohorts, such that its pharmacodynamic modulation was not dose dependent.

After 5 days of exposure to rapamycin or anti-EGFR antibody added at plating time, 49% and 71%, of TSC2−/− ASM cells, respectively, were not reactive with HMB45; anti-EGFR antibody was still more effective (Fig. 5B).

Rapamycin and DMSO were kept on the cells throughout the 30 mins recovery period (total time of exposure to rapamycin was 50 mins).

It is clear from this survey that the endocrine changes induced by 5 months of DR diet are in many ways distinct from those produced by 5 months of exposure to rapamycin at 14 ppm.

This confirmed that despite the relatively short time of exposure to rapamycin, the recruitment assay monitored transcript:ribosome re-association under two conditions in which eIF4E availability was altered.

Additionally, an optimal schedule for long-term exposures to rapamycin in cancer patients must be characterized.