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ProjectRun21 will be the first study to prospectively include running experience and running pace as primary exposures for development of RRI while following a specific running schedule for half-marathon.
In the exposure range from 6 to 15 ppm, the time-to-tumor appearance decreased with increasing exposure concentration (Monticello et al. 1996), i.e. lower concentrations require longer exposures for development of tumors.
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Future studies should prioritise exposure characterisation during both the prenatal and postnatal periods in order to disentangle the importance of the timing of maternal exposure for development of asthma in children.
The stronger association with household income in our study, compared with education, suggests that exposures related to low socioeconomic status that occur in adulthood may be as important as early-life exposures for COPD development.
If offspring of immigrants, with varying genetic background, experience the same change in age at the onset as observed in the offspring of natives, the importance of early environmental exposures for the development of type 1 diabetes would be further supported.
Another time interval of study exposure interest was the first 2 years of life, when infants/toddlers spend substantial amounts of time in the home; this may be a critical exposure window for development of allergy and asthma.
Cumulative exposure, however, might be more relevant than recent exposure for the development of PD.
In previous studies, exposure for fetal development was usually averaged over the longer third-trimester window.
An additional consideration is that the peripubertal period is likely not the only critical window of exposure for pubertal development.
A series of trypanocidal compounds were identified with suitable in vitro DMPK properties, including CNS exposure for further development.
Chronic diseases such as lung cancer require decades from initial exposure for the development of lung tumors.
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