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For cancers, exposures during the first year of life were also evaluated.
In conclusion, environmental exposures during the first year of life are associated with childhood asthma risk.
In models based on continuous exposure variables, SO2 exposures during the first trimester exhibited a significant association with LBW.
PM10 exposures during the first and second trimester of pregnancy were not significantly (p > 0.31) associated with placental mtDNA content.
Children who died during their first year of life (485 cases, 467 controls) were excluded from analyses of exposures during the first year.
There was a 33% and 36% increase in risk of LBW associated with maternal exposures during the first trimester to the > 75th percentile for PM10 and SO2, respectively.
Similar(28)
Exposures during the second and third trimesters were not ascertained.
They also monitored the mothers' personal air exposures during the third trimester using backpack monitors.
The dose response relationship was significant for both CO (p = 0.03) and NO2 (p < 0.001) exposures during the third trimesters.
An association between BTHM exposures during the third trimester and maternal MN frequency in BN was not evident.
Our finding of an effect with first trimester exposure, but not exposures during the second or third trimesters, is consistent with a number of other investigations.
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