Sentence examples for exposures during the earliest from inspiring English sources

Advances in stem cell biology that enable reprogramming of fibroblasts from individuals with complex diseases could be used to probe susceptibility to environmental exposures during the earliest stages of cell development.

However, among participants over 60 years of age, associations with PD appeared to be limited to pesticide exposures during the earlier (1974 –1989) time period.

Famine exposure during the early stage of life is related to a number of adulthood diseases.

Our ability to directly measure exposure during the early postpartum is a particular strength of this study.

Consistent with these studies was the finding that ethanol exposure during the early postnatal period in rats resulted in a marked reduction of CBP levels and histone acetylation in the developing cerebellum (Guo et al. 2011).

The dentine of the primary teeth provides evidence of exposure during the early childhood years, when hand-to-mouth activity is usually an important contributor to Pb body burden (Gulson 1996b).

rubripes), dmrt1 appears to be involved in the degeneration of germ cells in the ovary, which in turn, causes ovary to testis sex reversal induced by high-temperature exposure during the early development of gonads [ 87].

With regard to genistein, Delclos indicates that the use of dosed feed led to very low exposure during the early neonatal period because the transfer of genistein through the milk was minimal; thus, the exposure was too low to have an effect.

P-gp inhibitors increase the placental transfer of P-gp substrates in placental samples of late pregnancy [ 10]; however, the level of P-gp expression changes during pregnancy and the effect on fetal drug exposure during the early stage of pregnancy is not really known.

In this study we observed that exposure during the early months of pregnancy was associated with an increase in the percentage of T cells (CD3+ and CD4+) and a decrease in the percentage of B cells (CD19+), which may influence the Th1/Th2 homeostatic balance or create an environment that may lead to autoimmunity.

The past decade has seen an increasing understanding of the importance of the impact on chronic disease risk of exposures at all stages of life, especially exposures occurring during the early years of life when many organs are still undergoing rapid and formative growth [ 17].