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The study also benefitted from good quality data on smoking and occupational history, with job exposures assigned by experts.
Finally, the integrated dose response analysis assumes that the exposures assigned to each study subject are accurate representations of true exposure.
In our previous work, we reported modest effects using exposures assigned at a group level (based on neighborhood school measurements of traffic pollutants).
As a result, exposures assigned to residences may have under- or overestimated true annual average concentrations for the duration of follow-up.
Although it is not clear to us how override exposures were assigned, NIOSH/NCI did provide us with the override job codes and the exposures assigned to them.
Furthermore, models were examined excluding participants with exposures assigned to ZIP code centroids to evaluate the potential impact of exposure measurement error resulting from geocoding error.
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Exposure assigned as 1-week average of daily maxima or 24-hr measurements.
Our main analysis focused on exposure assigned according to residential postal codes at cohort entry.
Exposure assigned as a single 7-week average of daily maxima or 24-hr measurements.
Based on occupations, dust exposure assigned to 22% of the cases, vapour to 17% and smoke to 14%.
For this period of time, the HRT exposure assigned to each woman was based on her exposure status before and after the 18-month period.
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