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The oral bioavailability of Pb in food cooked or prepared with high Pb particulate water might also be a relevant route of exposure to study [26].
The specimens were subjected to various sequences of simulated seismic shear deformation and fire exposure to study the influence of multi-hazard interactions on the lateral load resistance of the walls.
Six replicate, 12-lead, digital electrocardiograms (ECGs) were recorded at 3 time points before and 5 time points after dosing to cover the time course of maximum exposure to study drugs and their metabolites.
A final 30-minute period was recorded at the end of the exposure to study the persistence of any observed effects.
In further experiments, we used 0.5 µg/ml Cd2+ and 12 h exposure to study the effects of KIN5 knockdown on Kin5 localization.
B[a]PDE-N2-dG adducts were determined by liquid chromatography-tandem mass spectrometry, and de novo mutations were measured in the cII-transgene, in Big Blue®mice exposed to benzo[a]pyrene (B[a]P; 3×50 mg/kg bw, i.p .. Spermatozoa were harvested at various time-points following exposure, to study the consequences of exposure during the different stages of spermatogenesis.
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Data of maternal exposure to studied pollutants were based on the primary residence and estimated from the average concentrations of each pollutant in each trimester.
Interpolation-based exposure assignment may also reduce the clustering of exposure estimates that can result from using MSA- or county-based averages to assign exposures to study subjects.
Once validated, these models can reduce exposure misclassification by allowing the assignment of individualized, rather than average, exposures to study subjects.
Mean exposures to study medication were 435.5 days in the linagliptin group and 422.4 days in the placebo group (medians 444 and 448 days, respectively).
Mean patient exposures to study medication were similar between treatment groups (85.0 and 84.0 days for indacaterol and placebo, respectively), and compliance was high in both groups (>97%).
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