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For sensitive subpopulations, specific guidance exists to balance benefits and risks of fish consumption versus methylmercury exposure to optimize brain development during gestation and infancy (4, 30).
In principle, simulation studies could be conducted to estimate the extent of exposure variability and contribution of various sources to the total exposure to optimize the exposure assessment [see, e.g., Whitaker et al. (2003) for an example from another field].
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Given the need to determine if symptoms are truly attributed to allergic mechanisms, it is important that family physicians consider diagnostic testing in conjunction with a careful examination of patient history, clinical evidence, and environmental exposure factors to optimize patient care.
Knowledge on the effects of tensile pre-strain exposure is necessary to optimize AF development for tissue reconstruction.
In order to obtain a preliminary estimate of the product (detector area) × (exposure time) needed to optimize the muon detector, we performed a simplified Monte Carlo calculation.
Multiple exposures were obtained to optimize linearity of signal.
For example, multiple (linear) regression methods have been used to optimize exposure model parameters for a subsample of subjects with measured exposures, and then model-based predictions are extrapolated to larger groups of subjects with no measured exposures.
Therefore, safety and efficacy may be addressed by designing HBOCs with modifications that limit hypertension, minimize heme destabilization and take into account endogenous Hb removal mechanisms to optimize exposure times for a given indication.
Stepping into her pristine, uber-organized house, it was apparent that she'd done everything possible to optimize exposure to the breathtaking vistas surrounding the property, even to the point of never hanging any window shades whatsoever.
A series of primary, secondary antibody dilutions and exposure times were used to optimize the experimental conditions for the linear sensitivity range of the autoradiography films (Santa Cruz Biotechnology, Santa Cruz, California, USA).
Future studies should aim to optimize exposure assessment by using more than two spot-urine samples.
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