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A limited number of rat studies have linked DEHP exposure to alterations in thyroid signaling and lower plasma thyroxine (T4) concentrations.
Several in vitro and in vivo rodent studies have linked increased Mn exposure to alterations in concentrations and metabolism of neurotransmitters, in particular, dopamine, GABA, and Glu (Burton and Guilarte 2009).
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Results from our study confirm earlier findings by Calderón et al. (2001) and Tsai et al. (2003) relating As exposure to memory alterations.
Our results indicate that prenatal DEX exposure led to alterations in neonate PFC gene expression of GR and calcyon, a risk gene for ADHD.
These model systems should enable us to be able to identify the critical cis (DNA) and trans (protein) cellular targets of heavy metal exposure leading to alterations in expression of specific susceptible genes.
Our data showed that pre-pubertal exposure to DBP produced alterations in testicular architecture as evident by poorly developed or mis-shaped testis, and altered spermatogenesis due to tubular degeneration and atrophy of seminiferous tubules especially in the high DBP dose (200 and 400 mg/kg) treated groups.
Exposure to Tat±morphine caused alterations in 90 of the 152 transcription factors collectively surveyed on TranSignal™ Protein/DNA Arrays I and II.
We believe that these doses were adequate for evaluating effects of actual environmental exposure to BPA on alterations in hormones and female reproduction in vivo.
The histological, molecular and functional experiments above have revealed that prenatal exposure to ketamine induces alterations of the cortical GABAergic system of Gad67-GFP adult mice.
We did not use total heart weight or right ventricular weight/body weight since we have previously reported that exposure to hypoxia produces alterations in body weight gain [ 5].
These results are important because they provide the first report, using data from a large-scale human population, of associations between elevated exposure to BPA and alterations in circulating hormone levels.
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