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In the presence of high glucose exposure, the development of endothelial cell dysfunction occurs with a reduction in SIRT1 expression and an increase in FoxO1 expression [ 180].
Possible causes of unexpected serum KL-6 elevation in patients with ILD include acute exacerbation of ILD, exacerbation of HP by increased antigen exposure, the development of PCP, CMV pneumonia, drug-induced pneumonitis, or adenocarcinoma of lung, breast, pancreas, ovary, colon and liver.
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In occupational exposures, the development of asthma requires long and repeated exposure, as occurs when workers are exposed to the damaged PVC material (Tuomainen et al. 2004).
The possibility exists that, due to differences between mouse and man in life expectancy, thymic involution, and antigen exposures, the development of CD4+CD25+ TR cells may occur in the periphery in man.
Cumulative exposure, however, might be more relevant than recent exposure for the development of PD.
To determine whether early life urban exposure predicts the development of obesity independently of later adulthood urban exposure, further analysis were done adjusting for later urban exposures.
However, we believe that prenatal exposure is likely to be more influential than postnatal exposure for the development of the central nervous system.
Consequently, workplace ETS exposure is not a confounder in the putative pathway between home ETS exposure and the development of COPD.
But the long lag between exposure and the development of mesothelioma means that the number of cases is still rising.
In animal studies, long-term prenatal nicotinic exposure alters the development of dopaminergic neurons.
This study was designed to assess the effects of prenatal cocaine exposure on the development of the serotonergic system.
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