Changes affecting exposure, susceptibility, risk, and health continue throughout life.
Computational toxicology can integrate biomarker data with knowledge of exposure, chemistry, biology, pharmacokinetics, toxicology, and epidemiology to inform the linkages among exposure, susceptibility, and human health.
2017 Thomas A. Neff Lecturer at the Thomas L. Petty Aspen Lung Conference, 60th Annual Meeting, "Environment and Global Lung Health: Exposure, Susceptibility and Intervention" Associate Director, Lead Physician Scientist, P50 Disease Investigation through Specialized Clinically-Oriented Ventures in Environment Research, 7/1/07-2013.
Although the search criteria encouraged examination of factors that influence the breadth of child health and development, attention was primarily focused on exposure, susceptibility, and outcome biomarkers associated with four important child health outcomes: autism and neurobehavioral disorders, injury, cancer, and asthma.
Open image in new window Fig. 1 Dimensions of disaster vulnerability as affected by exposure, susceptibility, and livelihood resilience.
The MOVE framework considers disaster vulnerability as a function of exposure, susceptibility (socially, economically, physically, culturally, environmentally, institutionally) and a lack of resilience.
Biologic monitoring has been widely used to assess exposures, susceptibility, and effects of chlorpyrifos and malathion; thus, the information base on these compounds is data rich.
The CHARGE (Childhood Autism Risks from Genetics and Environment) study will address a wide spectrum of chemical and biologic exposures, susceptibility factors, and their interactions.
The MICA design focuses on environmental exposures, susceptibility, asthma and other health measures, including risk factors associated with obesity and cardiovascular disease.
Research using biomarkers is carried out to learn about what a particular biomarker can tell the researchers about environmental exposures, susceptibility, or risks for adverse health outcomes from those exposures.
Especially important are studies to clarify the role of differential exposures, susceptibility, and diagnostic factors in cancer incidence, although differences in treatment may contribute to variations in cancer mortality.
