At 60 ppm CO exposure, significant differences (p < 0.05) are observed in both tissue samples, compared to control tissue.
Despite our finding significant correlations between inflammation and cumulative WTC exposure and significant differences in PSD between FDNY-FFs and TA-FFs, we could not detect a significant effect of cumulative WTC exposure on PSD.
Interestingly, we observed a significant increase in CypA levels in the nucleus compared with control conditions, starting 6 h after onset of glutamate exposure, without significant differences in its cytosolic levels.
The evaluation of trends based on station exposure ratings shows significant differences in temperature variables in both the 1895 2009 and 1970 2009 time periods.
Animals in the TBT exposure groups exhibited significant differences in body weight in F2 males but not females.
Conversely, 25 μg/ml EcEE exposure resulted in significant differences in mRNA levels of all three genes, corresponding to down regulation of both NCL and FOS (Log2 fold change = -0.813 ± 0.248 and -0.741 ± 0.078, respectively), and up regulation of p21 (Log2 fold change = 1.393 ± 0.128).
Differences in toxicokinetics between two persons with the same level of exposure could result in significant differences in the amount of a specific metabolite excreted in urine.
In a situation of relatively low risks, even relatively small improvements in exposure assessment may make significant differences in the studies.
In heterozgyotes, this shorter exposure still lead to significant differences in the neurocranium, in fact the difference in length between the treated wild-type and heterozygous embryos was even more marked (Fig. 1G; supplementary material Fig. S2).
Although when the same dose of oxaliplatin was combined with increasing doses of azacitidine (from 25to5050 mg/m), a reduction in mean oxaliplatin exposure was observed, no significant differences in the other non-compartmental modeled parameters estimated were observed.
