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The results show that prenatal alcohol exposure restricted to the second trimester equivalent alters the development of the CCpn dendritic arbor and the brain weight in a blood alcohol concentration (BAC -dependent manner.
We hypothesized that some of these beneficial effects could result from an exposure restricted to specific periods of life.
Salam proposed analysis of gestational and third-trimester exposure restricted to observations with 37 44 weeks gestation.
Although values were unaffected in the frontal cortex, both the occipital cortex and midbrain displayed significant increases after either continuous ETS exposure or ETS exposure restricted to the postnatal 6 13 month period.
Interestingly, only HFD exposure restricted to adulthood resulted in body weight gain, but this did not have a promotional effect on tumor development compared with continuous exposure to either LFD or HFD.
Specifically, in ESCAPE, elevated HRs were observed in models of PM2.5 exposure restricted to these two subtypes when compared with models of all cases (Raaschou-Nielsen et al. 2013).
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Moreover, TDCPP exposures restricted to the cleavage period [0.75 2 hpf (2-cell to 64-cell)] resulted in effects on survival and development similar to those from exposures at 0.75 96 hpf.
E-R trends among the particular sub-group of UG workers with >5-years tenure, a 15-year lag, and REC exposures restricted to <1280 µg/m-years were the basis for the authors' conclusion that these findings "provide further evidence that diesel exhaust increases risk" of lung cancer.
This HR of 5.01 is the highest HR in any of the expanded category models, indicating the strong effect of the a posteriori analyses, which excluded all workers with less than 5-years tenure: The authors' conclusion is based on workers with 15-year lags, exclusion of workers less than 5-years tenure, and cumulative exposures restricted to <1280 μg/m years for UG workers.
Some studies included both low-level and high-level lead exposures, restricting the conclusions regarding low-level lead exposure alone (Torres-Sanchez et al. 1999).
The excess appears to have been confined to a small group of HTS/MAG process workers with <1 year of exposure, and restricted to the period 15 30 years after first exposure.
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