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Rats were made dependent using the same chronic intermittent alcohol exposure protocol as in the previous experiments.
The extended exposure protocol (gestation day 5 through 20) appeared more sensitive for measuring fetotoxic effects.
Epidermal thickening was reduced in UVB-irradiated Cbl-b−/− mice compared to WT by the end of the UVB exposure protocol (Fig. 4c).
These effects on HRV were replicated in the second experiment in comparison to a similar white light exposure protocol (p ≤ .05).05
The adoption of a shared exposure protocol by the research community is strongly recommended since it is a key aspect to make biomonitoring surveys directly comparable, also in view of its recognition as a monitoring method by the EU legislation.
It is speculated that rather than the prenatal exposure protocol used here, the generation study design with both pre- and postnatal exposure may be preferable as a general screen to detect developmental immunotoxic injury after xenobiotic exposure.
The present 28 days oral toxicity study in Wistar rats was designed to facilitate detection of endocrine and immune modulating effects of decaBDE using an exposure protocol with improved bioavailability.
We designed a new exposure protocol to compare the biological responses of Xenopus laevis larvae exposed in semi-static conditions to size-reduced agglomerates of multi-walled carbon nanotubes (MWCNTs) in suspension in the water column and/or to larger agglomerates.
We conclude that these authors did not observe the effects reported by Schmidt et al. [1] because they used a substantially different exposure/recovery protocol instead of the continuous exposure protocol applied by Schmidt et al. [1].
Differences were observed between the first day and the fifth day and between the first day and the end of the exposure period when a general increase of CAT activity in controls and contaminated organisms were observed due to uncontrolled introduction of air under high pressure during the fifth day (see "Exposure protocol").
For the 11-day exposure protocol, mice were previously exposed to HBO for 1 h before PbA infection, whereas for the 4-day exposure protocol, PbA-infected mice were randomly selected and placed in the hyperbaric chamber.
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